The house is distinctive and unusual for south-central Indiana, a blend of Federal and Georgian styles of architecture more characteristic of southwest Pennsylvania, where Wylie was born and raised. It is one of the few pre-1840 structures that remains in Bloomington. The Wylie house contains an outstanding collection of early to mid-19th century American furnishings, including many Wylie family artifacts. A large collection of Wylie family letters and personal papers are housed in University Archives.
Visitors can also partake in programs at Wylie House including many volunteer opportunities, such as guiding tours, quilting, heirloom gardening, and seedsaving.