The museum's galleries are set up to allow changing exhibitions showcasing the extraordinary collections, special interpretive exhibits, and important works by contemporary Maine artists. Permanent exhibits include paintings, furnishings, and household objects with documented histories of ownership in the Saco valley in the 18th and 19th centuries. A re- created Colonial Revival kitchen presents a 1926 interpretation of early American food production and preparation. Federal and Victorian period bed chambers offer insights into the life-styles of prominent local families. The museum also has a 19th century display of natural history specimens, including birds of New England.
The museum offers on-going programs for students, adults, and families as public out- reach. The schedule includes walking tours, art classes and workshops, visiting lecture series, musical events, and a biennial historic house tour emphasizing art, history, and culture.